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Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study

Overview of attention for article published in Acta Cirurgica Brasileira, August 2015
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Title
Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation of the skin? An experimental study
Published in
Acta Cirurgica Brasileira, August 2015
DOI 10.1590/s0102-865020150080000002
Pubmed ID
Authors

Jose Octavio Gonçalves de Freitas, Paulo Rogério Quieregatto, Bernardo Hochman, Guilherme Abbud Franco Lapin, Stella Maria Botequio Mella, Jessica Ruivo Maximino, Gerson Chadi, Lydia Masako Ferreira

Abstract

To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats. Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) was injected with 10.0 mg/kg dexamethasone. In all groups, the three subcutaneous injections were performed 30 minutes prior to the surgical skin incision and tissue collection. SP and CGRP (15 kDa pro-CGRP and 5 kDa CGRP) were quantified by Western Blotting. No statistically significant differences (p>0.05) were found in pro-CGRP, CGRP and SP values in all three groups. The anti-inflammatory effect of dexamethasone did not occur when the substance P and calcitonin gene-related peptide levels were altered during the neurogenic inflammation process of skin wound healing in rats.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Student > Bachelor 3 16%
Student > Ph. D. Student 3 16%
Student > Master 2 11%
Other 1 5%
Other 0 0%
Unknown 6 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 21%
Medicine and Dentistry 2 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Nursing and Health Professions 1 5%
Computer Science 1 5%
Other 3 16%
Unknown 7 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2016.
All research outputs
#16,462,378
of 25,988,468 outputs
Outputs from Acta Cirurgica Brasileira
#3
of 3 outputs
Outputs of similar age
#147,958
of 277,646 outputs
Outputs of similar age from Acta Cirurgica Brasileira
#3
of 9 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3 research outputs from this source. They receive a mean Attention Score of 1.6. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,646 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.