Title |
Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates
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Published in |
Brazilian Journal of Microbiology, May 2015
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DOI | 10.1590/s1517-838246120120442 |
Pubmed ID | |
Authors |
Laura Bedin Denardi, Débora Alves Nunes Mario, Érico Silva Loreto, Janio Morais Santurio, Sydney Hartz Alves |
Abstract |
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata , a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro , notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 15% |
Student > Master | 5 | 15% |
Student > Bachelor | 4 | 12% |
Student > Doctoral Student | 4 | 12% |
Student > Ph. D. Student | 3 | 9% |
Other | 6 | 18% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 9 | 27% |
Medicine and Dentistry | 6 | 18% |
Agricultural and Biological Sciences | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 1 | 3% |
Unknown | 10 | 30% |