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Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials

Overview of attention for article published in Anais Brasileiros de Dermatologia, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#32 of 575)
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

news
2 news outlets
twitter
7 X users

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
62 Mendeley
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Title
Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials
Published in
Anais Brasileiros de Dermatologia, February 2017
DOI 10.1590/abd1806-4841.20175070
Pubmed ID
Authors

Romi Bloom, Kyle T. Amber

Abstract

Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions, particularly Stevens-Johnson syndrome/toxic epidermal necrolysis. Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria. In total, 18,698 patients were included with 1,570 (8.3%) of patients experiencing an adverse dermatologic reaction. The incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis was 0.04%.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 15%
Other 8 13%
Student > Bachelor 6 10%
Researcher 6 10%
Student > Doctoral Student 3 5%
Other 9 15%
Unknown 21 34%
Readers by discipline Count As %
Medicine and Dentistry 15 24%
Neuroscience 5 8%
Nursing and Health Professions 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 6 10%
Unknown 25 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2021.
All research outputs
#1,750,206
of 25,988,468 outputs
Outputs from Anais Brasileiros de Dermatologia
#32
of 575 outputs
Outputs of similar age
#35,540
of 429,193 outputs
Outputs of similar age from Anais Brasileiros de Dermatologia
#1
of 3 outputs
Altmetric has tracked 25,988,468 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 575 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,193 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them