↓ Skip to main content

Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials*

Overview of attention for article published in Anais Brasileiros de Dermatologia, January 2017
Altmetric Badge

Mentioned by

news
2 news outlets
twitter
7 X users

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
59 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Identifying the incidence of rash, Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: a systematic review of 122 randomized controlled trials*
Published in
Anais Brasileiros de Dermatologia, January 2017
DOI 10.1590/abd1806-4841.20175070
Pubmed ID
Authors

Romi Bloom, Kyle T. Amber

Abstract

Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions, particularly Stevens-Johnson syndrome/toxic epidermal necrolysis. Of a total of 4,364 papers regarding lamotrigine, 122 studies met our inclusion and exclusion criteria. In total, 18,698 patients were included with 1,570 (8.3%) of patients experiencing an adverse dermatologic reaction. The incidence of Stevens-Johnson syndrome/toxic epidermal necrolysis was 0.04%.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 15%
Researcher 6 10%
Other 6 10%
Student > Bachelor 6 10%
Student > Doctoral Student 3 5%
Other 9 15%
Unknown 20 34%
Readers by discipline Count As %
Medicine and Dentistry 13 22%
Neuroscience 5 8%
Nursing and Health Professions 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 6 10%
Unknown 24 41%