Immunity related disorder is one of the leading causes of disease in the world. Oxidative stress and microbial infections play a major role in inflammation-induced diseases. Bovine colostrum (BC) contains immunoglobulins and lactoferrins which help in building the immunity and protect against the bacterial proliferation and growth.
This study was designed to investigate the antimicrobial and antiinflammatory activities of BC.
Antimicrobial activity was determined by the pour-plate method using five different strains of bacteria (Gram -ve and +ve), and carrageenan-induced rat paw edema method was used for the evaluation of antiinflammatory activity in adult Wistar rats. Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent.
BC showed significant antimicrobial activity against E. coli, S. aureus, P. vulgaris, E. aerogenes and S. typhi. At 100 µg/mL of BC, the inhibition zones were found to be 13 mm, 11 mm, 12 mm, 12 mm, and 11 mm, respectively. The BC zones were comparatively smaller than those of amoxicillin at 10 µg/mL, where the inhibition zones were 16 mm, 30 mm, 23 mm, 22 mm and 23 mm, respectively. In the BC treated animals, the percentage edema inhibition was found to be 67.94% at the third hour, suggesting high antiinflammatory activity of BC in rats.
BC may be beneficial in reducing the risks of inflammation associated diseases. Further studies are needed before BC can be recommended for therapeutic interventions in humans.
Pharmacology, Toxicology and Pharmaceutical Science
5
11%
Medicine and Dentistry
5
11%
Immunology and Microbiology
4
9%
Veterinary Science and Veterinary Medicine
3
7%
Other
4
9%
Unknown
17
38%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2025.
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#898,302
of 34,410,315 outputs
Outputs from Recent Patents on Inflammation & Allergy Drug Discovery
#5
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Outputs of similar age
#12,031
of 446,410 outputs
Outputs of similar age from Recent Patents on Inflammation & Allergy Drug Discovery
#1
of 4 outputs
Altmetric has tracked 34,410,315 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 119 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,410 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them
