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Antibacterial and Antiinflammatory Properties of Bovine Colostrum.

Overview of attention for article published in Recent Advances in Inflammation & Allergy Drug Discovery, January 2016
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Antibacterial and Antiinflammatory Properties of Bovine Colostrum.
Published in
Recent Advances in Inflammation & Allergy Drug Discovery, January 2016
DOI 10.2174/1872214810666160219163118
Pubmed ID

Ramesh Yadav, Trupti Angolkar, Ginpreet Kaur, Harpal S Buttar


Immunity related disorder is one of the leading causes of disease in the world. Oxidative stress and microbial infections play a major role in inflammation-induced diseases. Bovine colostrum (BC) contains immunoglobulins and lactoferrins which help in building the immunity and protect against the bacterial proliferation and growth. This study was designed to investigate the antimicrobial and antiinflammatory activities of BC. Antimicrobial activity was determined by the pour-plate method using five different strains of bacteria (Gram -ve and +ve), and carrageenan-induced rat paw edema method was used for the evaluation of antiinflammatory activity in adult Wistar rats. Diclofenac was used as standard antiinflammatory drug, and amoxicillin was used as standard antimicrobial agent. BC showed significant antimicrobial activity against E. coli, S. aureus, P. vulgaris, E. aerogenes and S. typhi. At 100 µg/mL of BC, the inhibition zones were found to be 13 mm, 11 mm, 12 mm, 12 mm, and 11 mm, respectively. The BC zones were comparatively smaller than those of amoxicillin at 10 µg/mL, where the inhibition zones were 16 mm, 30 mm, 23 mm, 22 mm and 23 mm, respectively. In the BC treated animals, the percentage edema inhibition was found to be 67.94% at the third hour, suggesting high antiinflammatory activity of BC in rats. BC may be beneficial in reducing the risks of inflammation associated diseases. Further studies are needed before BC can be recommended for therapeutic interventions in humans.

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Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Other 6 14%
Student > Ph. D. Student 6 14%
Student > Bachelor 5 12%
Student > Master 4 9%
Researcher 3 7%
Other 8 19%
Unknown 11 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 12%
Medicine and Dentistry 5 12%
Immunology and Microbiology 4 9%
Veterinary Science and Veterinary Medicine 3 7%
Other 4 9%
Unknown 16 37%