Title |
NGF and therapeutic prospective: what have we learned from the NGF transgenic models?
|
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Published in |
Annali dell'Istituto Superiore di Sanità, January 2015
|
DOI | 10.4415/ann_15_01_03 |
Pubmed ID | |
Authors |
Luigi Aloe, Maria Luisa Rocco |
Abstract |
It has been shown that topical nerve growth factor (NGF) administration induces healing action on human cutaneous, corneal and pressure ulcers, glaucoma, maculopathy and retinitis pigmentosa suggesting a therapeutic potential of NGF in human ophthalmology and cutaneous ulcers. A similar therapeutic suggestion has emerged for the NGF gene therapy of Alzheimer's disease and ischemic heart injury. Moreover, over the last few years, the role and biological properties of NGF have also been investigated with transgenic mice over-expressing and down-expressing NGF. However, the results obtained with these transgenic mice seem suitable to confirm and/or support the evidence obtained with exogenous administration of NGF regarding the suggested clinical potentiality of NGF. The aim of the present brief review is to report and comment on these two different findings of NGF's healing properties. |
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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France | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 18% |
Student > Master | 3 | 14% |
Researcher | 3 | 14% |
Student > Doctoral Student | 2 | 9% |
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Other | 2 | 9% |
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Agricultural and Biological Sciences | 1 | 5% |
Other | 4 | 18% |
Unknown | 8 | 36% |