Title |
The Essential Medicinal Chemistry of Curcumin
|
---|---|
Published in |
Journal of Medicinal Chemistry, January 2017
|
DOI | 10.1021/acs.jmedchem.6b00975 |
Pubmed ID | |
Authors |
Kathryn M. Nelson, Jayme L. Dahlin, Jonathan Bisson, James Graham, Guido F. Pauli, Michael A. Walters |
Abstract |
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed. |
X Demographics
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Japan | 46 | 7% |
India | 31 | 5% |
United Kingdom | 22 | 4% |
Canada | 17 | 3% |
France | 9 | 1% |
Germany | 8 | 1% |
Spain | 8 | 1% |
Mongolia | 8 | 1% |
Other | 85 | 14% |
Unknown | 284 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 467 | 75% |
Scientists | 118 | 19% |
Practitioners (doctors, other healthcare professionals) | 27 | 4% |
Science communicators (journalists, bloggers, editors) | 11 | 2% |
Unknown | 2 | <1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Australia | 2 | <1% |
Switzerland | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
India | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
Unknown | 1861 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 280 | 15% |
Student > Master | 250 | 13% |
Student > Ph. D. Student | 213 | 11% |
Researcher | 173 | 9% |
Other | 83 | 4% |
Other | 305 | 16% |
Unknown | 569 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 275 | 15% |
Biochemistry, Genetics and Molecular Biology | 201 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 170 | 9% |
Agricultural and Biological Sciences | 148 | 8% |
Medicine and Dentistry | 134 | 7% |
Other | 281 | 15% |
Unknown | 664 | 35% |