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Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Overview of attention for article published in Science, April 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
15 news outlets
blogs
3 blogs
twitter
121 X users
facebook
1 Facebook page
googleplus
5 Google+ users

Readers on

mendeley
606 Mendeley
citeulike
3 CiteULike
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Title
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
Published in
Science, April 2016
DOI 10.1126/science.aad8852
Pubmed ID
Authors

Simone S Li, Ana Zhu, Vladimir Benes, Paul I Costea, Rajna Hercog, Falk Hildebrand, Jaime Huerta-Cepas, Max Nieuwdorp, Jarkko Salojärvi, Anita Y Voigt, Georg Zeller, Shinichi Sunagawa, Willem M de Vos, Peer Bork

Abstract

Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.

X Demographics

X Demographics

The data shown below were collected from the profiles of 121 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 606 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 2%
Denmark 5 <1%
Germany 3 <1%
Canada 3 <1%
United Kingdom 2 <1%
New Zealand 1 <1%
Belgium 1 <1%
Switzerland 1 <1%
China 1 <1%
Other 3 <1%
Unknown 573 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 133 22%
Researcher 127 21%
Student > Master 70 12%
Student > Bachelor 36 6%
Other 29 5%
Other 104 17%
Unknown 107 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 159 26%
Biochemistry, Genetics and Molecular Biology 102 17%
Medicine and Dentistry 71 12%
Immunology and Microbiology 69 11%
Environmental Science 11 2%
Other 62 10%
Unknown 132 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 200. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2022.
All research outputs
#200,832
of 25,728,855 outputs
Outputs from Science
#5,768
of 83,264 outputs
Outputs of similar age
#3,597
of 313,561 outputs
Outputs of similar age from Science
#105
of 1,134 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,264 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,134 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.