| Title |
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus - Volume 23, Number 8—August 2017 - Emerging Infectious Diseases journal - CDC
|
|---|---|
| Published in |
Emerging Infectious Diseases, August 2017
|
| DOI | 10.3201/eid2308.170036 |
| Pubmed ID | |
| Authors |
Andrew D. Haddow, Aysegul Nalca, Franco D. Rossi, Lynn J. Miller, Michael R. Wiley, Unai Perez-Sautu, Samuel C. Washington, Sarah L. Norris, Suzanne E. Wollen-Roberts, Joshua D. Shamblin, Adrienne E. Kimmel, Holly A. Bloomfield, Stephanie M. Valdez, Thomas R. Sprague, Lucia M. Principe, Stephanie A. Bellanca, Stephanie S. Cinkovich, Luis Lugo-Roman, Lisa H. Cazares, William D. Pratt, Gustavo F. Palacios, Sina Bavari, M. Louise Pitt, Farooq Nasar |
| Abstract |
Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia in 75% of macaques and virus RNA in 100%, followed by seroconversion. In macaques inoculated intrarectally, we detected viremia, virus RNA, or both, in 100% of both species, followed by seroconversion. The magnitude and duration of infectious virus in blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 59% |
| United Kingdom | 1 | 6% |
| Belgium | 1 | 6% |
| Ecuador | 1 | 6% |
| Unknown | 4 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 71% |
| Practitioners (doctors, other healthcare professionals) | 3 | 18% |
| Scientists | 2 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 19% |
| Student > Ph. D. Student | 8 | 13% |
| Other | 6 | 10% |
| Student > Master | 6 | 10% |
| Student > Bachelor | 5 | 8% |
| Other | 14 | 23% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 13 | 21% |
| Medicine and Dentistry | 9 | 15% |
| Agricultural and Biological Sciences | 9 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Veterinary Science and Veterinary Medicine | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 14 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2020.
All research outputs
#851,825
of 25,382,440 outputs
Outputs from Emerging Infectious Diseases
#1,005
of 9,718 outputs
Outputs of similar age
#17,486
of 326,133 outputs
Outputs of similar age from Emerging Infectious Diseases
#8
of 119 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,718 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.7. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.