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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Engineering Antigen-Specific T Cells from Genetically Modified Human Hematopoietic Stem Cells in Immunodeficient Mice
|
|---|---|
| Published in |
PLOS ONE, December 2009
|
| DOI | 10.1371/journal.pone.0008208 |
| Pubmed ID | |
| Authors |
Scott G. Kitchen, Michael Bennett, Zoran Galić, Joanne Kim, Qing Xu, Alan Young, Alexis Lieberman, Aviva Joseph, Harris Goldstein, Hwee Ng, Otto Yang, Jerome A. Zack |
| Abstract |
There is a desperate need for effective therapies to fight chronic viral infections. The immune response is normally fastidious at controlling the majority of viral infections and a therapeutic strategy aimed at reestablishing immune control represents a potentially powerful approach towards treating persistent viral infections. We examined the potential of genetically programming human hematopoietic stem cells to generate mature CD8+ cytotoxic T lymphocytes that express a molecularly cloned, "transgenic" human anti-HIV T cell receptor (TCR). Anti-HIV TCR transduction of human hematopoietic stem cells directed the maturation of a large population of polyfunctional, HIV-specific CD8+ cells capable of recognizing and killing viral antigen-presenting cells. Thus, through this proof-of-concept we propose that genetic engineering of human hematopoietic stem cells will allow the tailoring of effector T cell responses to fight HIV infection or other diseases that are characterized by the loss of immune control. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 2% |
| United States | 1 | 2% |
| Germany | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 53 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 30% |
| Researcher | 12 | 21% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 11% |
| Professor > Associate Professor | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 39% |
| Medicine and Dentistry | 11 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Immunology and Microbiology | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 3 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#2,570,544
of 22,681,577 outputs
Outputs from PLOS ONE
#32,488
of 193,576 outputs
Outputs of similar age
#13,439
of 164,992 outputs
Outputs of similar age from PLOS ONE
#104
of 564 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,576 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,992 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 564 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.