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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential
|
|---|---|
| Published in |
Environmental Health, July 2016
|
| DOI | 10.1186/s12940-016-0157-5 |
| Pubmed ID | |
| Authors |
Xian Zhang, Norbert Staimer, Tomas Tjoa, Daniel L. Gillen, James J. Schauer, Martin M. Shafer, Sina Hasheminassab, Payam Pakbin, John Longhurst, Constantinos Sioutas, Ralph J. Delfino |
| Abstract |
Short-term exposure to ambient air pollution has been associated with acute increases in cardiovascular hospitalization and mortality. However, causative chemical components and underlying pathophysiological mechanisms remain to be clarified. We hypothesized that endothelial dysfunction would be associated with mobile-source (traffic) air pollution and that pollutant components with higher oxidative potential to generate reactive oxygen species (ROS) would have stronger associations. We carried out a cohort panel study in 93 elderly non-smoking adults living in the Los Angeles metropolitan area, during July 2012-February 2014. Microvascular function, represented by reactive hyperemia index (RHI), was measured weekly for up to 12 weeks (N = 845). Air pollutant data included daily data from regional air-monitoring stations, five-day average PM chemical components and oxidative potential in three PM size-fractions, and weekly personal nitrogen oxides (NOx). Linear mixed-effect models estimated adjusted changes in microvascular function with exposure. RHI was inversely associated with traffic-related pollutants such as ambient PM2.5 black carbon (BC), NOx, and carbon monoxide (CO). An interquartile range change increase (1.06 μg/m(3)) in 5-day average BC was associated with decreased RHI, -0.093 (95 % CI: -0.151, -0.035). RHI was inversely associated with other mobile-source components/tracers (polycyclic aromatic hydrocarbons, elemental carbon, and hopanes), and PM oxidative potential as quantified in two independent assays (dithiothreitol and in vitro macrophage ROS) in accumulation and ultrafine PM, and transition metals. Our findings suggest that short-term exposures to traffic-related air pollutants with high oxidative potential are major components contributing to microvascular dysfunction. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 17% |
| Student > Master | 19 | 16% |
| Student > Ph. D. Student | 17 | 14% |
| Student > Bachelor | 9 | 7% |
| Student > Doctoral Student | 5 | 4% |
| Other | 18 | 15% |
| Unknown | 32 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 21 | 17% |
| Medicine and Dentistry | 18 | 15% |
| Nursing and Health Professions | 9 | 7% |
| Engineering | 7 | 6% |
| Chemistry | 6 | 5% |
| Other | 29 | 24% |
| Unknown | 31 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#13,985,864
of 22,881,154 outputs
Outputs from Environmental Health
#1,005
of 1,495 outputs
Outputs of similar age
#208,555
of 365,298 outputs
Outputs of similar age from Environmental Health
#14
of 27 outputs
Altmetric has tracked 22,881,154 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,495 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.3. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,298 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.