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Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium

Overview of attention for article published in Scientific Reports, July 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 33,284)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
50 Mendeley
Title
Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium
Published in
Scientific Reports, July 2016
DOI 10.1038/srep29901
Pubmed ID
Authors

Michael D. Delp, Jacqueline M. Charvat, Charles L. Limoli, Ruth K. Globus, Payal Ghosh, Delp, Michael D, Charvat, Jacqueline M, Limoli, Charles L, Globus, Ruth K, Ghosh, Payal

Abstract

As multiple spacefaring nations contemplate extended manned missions to Mars and the Moon, health risks could be elevated as travel goes beyond the Earth's protective magnetosphere into the more intense deep space radiation environment. The primary purpose of this study was to determine whether mortality rates due to cardiovascular disease (CVD), cancer, accidents and all other causes of death differ in (1) astronauts who never flew orbital missions in space, (2) astronauts who flew only in low Earth orbit (LEO), and (3) Apollo lunar astronauts, the only humans to have traveled beyond Earth's magnetosphere. Results show there were no differences in CVD mortality rate between non-flight (9%) and LEO (11%) astronauts. However, the CVD mortality rate among Apollo lunar astronauts (43%) was 4-5 times higher than in non-flight and LEO astronauts. To test a possible mechanistic basis for these findings, a secondary purpose was to determine the long-term effects of simulated weightlessness and space-relevant total-body irradiation on vascular responsiveness in mice. The results demonstrate that space-relevant irradiation induces a sustained vascular endothelial cell dysfunction. Such impairment is known to lead to occlusive artery disease, and may be an important risk factor for CVD among astronauts exposed to deep space radiation.

Twitter Demographics

The data shown below were collected from the profiles of 301 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 8%
Germany 1 2%
United Kingdom 1 2%
Brazil 1 2%
Japan 1 2%
Argentina 1 2%
Unknown 41 82%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 26%
Researcher 9 18%
Other 6 12%
Student > Master 6 12%
Professor > Associate Professor 6 12%
Other 10 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 22%
Medicine and Dentistry 8 16%
Engineering 7 14%
Biochemistry, Genetics and Molecular Biology 6 12%
Computer Science 4 8%
Other 14 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1866. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2017.
All research outputs
#351
of 8,084,227 outputs
Outputs from Scientific Reports
#3
of 33,284 outputs
Outputs of similar age
#28
of 257,550 outputs
Outputs of similar age from Scientific Reports
#1
of 3,252 outputs
Altmetric has tracked 8,084,227 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,284 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,550 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 3,252 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.