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Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms

Overview of attention for article published in International Immunopharmacology, August 2015
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Title
Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms
Published in
International Immunopharmacology, August 2015
DOI 10.1016/j.intimp.2015.08.019
Pubmed ID
Authors

Ashok Kumar Pandurangan, Nooshin Mohebali, Norhaizan Mohd. Esa, Chung Yeng Looi, Salmiah Ismail, Zeinab Saadatdoust

Abstract

Inflammatory bowel diseases (IBD) encompass at least two forms of intestinal inflammation: Crohn's disease and ulcerative colitis (UC). Both conditions are chronic and inflammatory disorders in the gastrointestinal tract, with an increasing prevalence being associated with the industrialization of nations and in developing countries. Patients with these disorders are 10 to 20 times more likely to develop cancer of the colon. The aim of this study was to characterize the effects of a naturally occurring polyphenol, gallic acid (GA), in an experimental murine model of UC. A significant blunting of weight loss and clinical symptoms was observed in dextran sodium sulfate (DSS)-exposed, GA-treated mice compared with control mice. This effect was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the expression of inflammatory mediators, such as inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and pro-inflammatory cytokines. In addition, GA reduced the activation and nuclear accumulation of p-STAT3(Y705), preventing the degradation of the inhibitory protein IκB and inhibiting of the nuclear translocation of p65-NF-κB in colonic mucosa. These findings suggest that GA exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of p65-NF-κB and IL-6/p-STAT3(Y705) activation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 97 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 17%
Student > Ph. D. Student 15 15%
Student > Bachelor 10 10%
Student > Doctoral Student 8 8%
Student > Postgraduate 6 6%
Other 13 13%
Unknown 29 30%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 13 13%
Agricultural and Biological Sciences 13 13%
Biochemistry, Genetics and Molecular Biology 6 6%
Medicine and Dentistry 5 5%
Chemistry 4 4%
Other 17 17%
Unknown 40 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#22,759,802
of 25,374,647 outputs
Outputs from International Immunopharmacology
#3,307
of 4,480 outputs
Outputs of similar age
#239,904
of 279,607 outputs
Outputs of similar age from International Immunopharmacology
#40
of 68 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.