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Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Co-Repressor of Neurospora crassa

Overview of attention for article published in Genetics, July 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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5 tweeters
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1 Facebook page

Citations

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5 Dimensions

Readers on

mendeley
28 Mendeley
Title
Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Co-Repressor of Neurospora crassa
Published in
Genetics, July 2016
DOI 10.1534/genetics.116.191064
Pubmed ID
Authors

Consuelo Olivares-Yañez, Jillian Emerson, Arminja Kettenbach, Jennifer J. Loros, Jay C. Dunlap, Luis F. Larrondo, Olivares-Yañez, Consuelo, Emerson, Jillian, Kettenbach, Arminja, Loros, Jennifer J, Dunlap, Jay C, Larrondo, Luis F, C. Olivares-Yanez, J. Emerson, A. Kettenbach, J. J. Loros, J. C. Dunlap, L. F. Larrondo

Abstract

Neurospora crassa is a model organism for the study of circadian clocks, molecular machineries that confer circa 24 h rhythms to different processes at the cellular and organismal level. The FREQUENCY (FRQ) protein is a central component of the Neurospora core-clock, a transcription-translation negative feedback loop that controls genome-wide rhythmic gene expression. A genetic screen aimed at determining new components involved in the latter process identified rco-1 (regulation of conidiation-1), the ortholog of the Saccharomyces cerevisiae Tup1 co-repressor, as affecting period length. By employing bioluminescent transcriptional and translational fusion reporters we evaluated frq and FRQ expression levels in the rco-1 mutant background observing that, in contrast to prior reports, frq and FRQ expression are robustly rhythmic in the absence of RCO-1 although both amplitude and period length of the core-clock are affected. Moreover, we detected a defect in metabolic compensation, such that high-glucose concentrations in the medium result in a significant decrease in period when RCO-1 is absent. Proteins physically interacting with RCO-1 were identified through co-immunoprecipitation and mass-spectrometry; these include several components involved in chromatin remodeling and transcription, some of which, when absent, lead to a slight change in period. In the aggregate, these results indicate a dual role for RCO-1: although it is not essential for core-clock function, it regulates proper period and amplitude of core-clock dynamics, and is also required for the rhythmic regulation of several clock-controlled genes.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Ph. D. Student 4 14%
Student > Master 3 11%
Student > Bachelor 2 7%
Student > Doctoral Student 2 7%
Other 3 11%
Unknown 8 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 32%
Biochemistry, Genetics and Molecular Biology 8 29%
Unspecified 1 4%
Energy 1 4%
Medicine and Dentistry 1 4%
Other 0 0%
Unknown 8 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 February 2017.
All research outputs
#2,144,493
of 9,059,586 outputs
Outputs from Genetics
#1,600
of 3,827 outputs
Outputs of similar age
#76,339
of 263,911 outputs
Outputs of similar age from Genetics
#44
of 83 outputs
Altmetric has tracked 9,059,586 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,827 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,911 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.