Title |
Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes
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Published in |
BMC Genomic Data, October 2012
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DOI | 10.1186/1471-2156-13-86 |
Pubmed ID | |
Authors |
Chuang Chen, Carolyn TA Herzig, Leeson J Alexander, John W Keele, Tara G McDaneld, Janice C Telfer, Cynthia L Baldwin |
Abstract |
WC1 co-receptors belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multi-gene family. Expression of particular WC1 genes defines functional subpopulations of WC1(+) γδ T cells. We have previously identified partial or complete genomic sequences for thirteen different WC1 genes through annotation of the bovine genome Btau_3.1 build. We also identified two WC1 cDNA sequences from other cattle that did not correspond to sequences in the Btau_3.1 build. Their absence in the Btau_3.1 build may have reflected gaps in the genome assembly or polymorphisms among animals. Since the response of γδ T cells to bacterial challenge is determined by WC1 gene expression, it was critical to understand whether individual cattle or breeds differ in the number of WC1 genes or display polymorphisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 26% |
Student > Doctoral Student | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 1 | 5% |
Student > Bachelor | 1 | 5% |
Other | 4 | 21% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 26% |
Veterinary Science and Veterinary Medicine | 3 | 16% |
Immunology and Microbiology | 2 | 11% |
Chemistry | 2 | 11% |
Mathematics | 1 | 5% |
Other | 2 | 11% |
Unknown | 4 | 21% |