OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

Overview of attention for article published in Frontiers in Pharmacology, February 2021

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RT @FrontPharmacol: New Research: OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance https://t.co/QznpLlNE9v #pharm…

23 Mar 2021

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New Research: OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance https://t.co/QznpLlNE9v #pharmacology

23 Mar 2021

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OTS964 薬剤耐性タンパクABCG2の発現で薬効減弱。低濃度でABCG2発現増加させる(耐性を強めてしまう)。高濃度ではABCG2の基質のように結合し、機能を低下。なんというか非常に扱いにくい印象。他のTOPK阻害剤はこの辺りを克服できてるのか、遺伝子発現確認してゴリ押し？ https://t.co/GXvHbnu3ON

08 Mar 2021

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