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Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats

Overview of attention for article published in Nutrition & Metabolism, January 2007
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

twitter
1 tweeter
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1 patent
facebook
1 Facebook page

Citations

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27 Dimensions

Readers on

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20 Mendeley
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1 CiteULike
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Title
Effect of pre-germinated brown rice intake on diabetic neuropathy in streptozotocin-induced diabetic rats
Published in
Nutrition & Metabolism, January 2007
DOI 10.1186/1743-7075-4-25
Pubmed ID
Authors

Seigo Usuki, Yukihiko Ito, Keiko Morikawa, Mitsuo Kise, Toshio Ariga, Michael Rivner, Robert K Yu

Abstract

To study the effects of a pre-germinated brown rice diet (PR) on diabetic neuropathy in streptozotocin (STZ)-induced diabetic rats. The effects of a PR diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with those fed brown rice (BR) or white rice (WR) diets with respect to the following parameters: blood-glucose level, motor-nerve conduction velocity (NCV), sciatic-nerve Na+/K+-ATPase activity, and serum homocysteine-thiolactonase (HTase) activity. Compared with diabetic rats fed BR or WR diets, those fed a PR diet demonstrated significantly lower blood-glucose levels (p < 0.001), improved NCV (1.2- and 1.3-fold higher, respectively), and increased Na+/K+-ATPase activity (1.6- and 1.7-fold higher, respectively). The PR diet was also able to normalize decreased serum homocysteine levels normally seen in diabetic rats. The increased Na+/K+-ATPase activity observed in rats fed PR diets was associated with elevations in HTase activity (r = 0.913, p < 0.001). The in vitro effect of the total lipid extract from PR bran (TLp) on the Na+/K+-ATPase and HTase activity was also examined. Incubation of homocysteine thiolactone (HT) with low-density lipoprotein (LDL) in vitro resulted in generation of HT-modified LDL, which possessed high potency to inhibit Na+/K+-ATPase activity in the sciatic nerve membrane. The inhibitory effect of HT-modified LDL on Na+/K+-ATPase activity disappeared when TLp was added to the incubation mixture. Furthermore, TLp directly activated the HTase associated with high-density lipoprotein (HDL). PR treatment shows efficacy for protecting diabetic deterioration and for improving physiological parameters of diabetic neuropathy in rats, as compared with a BR or WR diet. This effect may be induced by a mechanism whereby PR intake mitigates diabetic neuropathy by one or more factors in the total lipid fraction. The active lipid fraction is able to protect the Na+/K+-ATPase of the sciatic-nerve membrane from the toxicity of HT-modified LDL and to directly activate the HTase of HDL.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 35%
Student > Bachelor 3 15%
Researcher 2 10%
Other 2 10%
Professor 1 5%
Other 4 20%
Unknown 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 25%
Chemistry 5 25%
Biochemistry, Genetics and Molecular Biology 4 20%
Medicine and Dentistry 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 2 10%
Unknown 1 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2014.
All research outputs
#2,812,929
of 11,247,926 outputs
Outputs from Nutrition & Metabolism
#283
of 588 outputs
Outputs of similar age
#27,952
of 120,545 outputs
Outputs of similar age from Nutrition & Metabolism
#8
of 18 outputs
Altmetric has tracked 11,247,926 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 588 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 120,545 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.