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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro
|
|---|---|
| Published in |
PLOS ONE, October 2012
|
| DOI | 10.1371/journal.pone.0048277 |
| Pubmed ID | |
| Authors |
Eva Sapi, Scott L. Bastian, Cedric M. Mpoy, Shernea Scott, Amy Rattelle, Namrata Pabbati, Akhila Poruri, Divya Burugu, Priyanka A. S. Theophilus, Truc V. Pham, Akshita Datar, Navroop K. Dhaliwal, Alan MacDonald, Michael J. Rossi, Saion K. Sinha, David F. Luecke |
| Abstract |
Borrelia burgdorferi, the causative agent of Lyme disease, has long been known to be capable of forming aggregates and colonies. It was recently demonstrated that Borrelia burgdorferi aggregate formation dramatically changes the in vitro response to hostile environments by this pathogen. In this study, we investigated the hypothesis that these aggregates are indeed biofilms, structures whose resistance to unfavorable conditions are well documented. We studied Borrelia burgdorferi for several known hallmark features of biofilm, including structural rearrangements in the aggregates, variations in development on various substrate matrices and secretion of a protective extracellular polymeric substance (EPS) matrix using several modes of microscopic, cell and molecular biology techniques. The atomic force microscopic results provided evidence that multilevel rearrangements take place at different stages of aggregate development, producing a complex, continuously rearranging structure. Our results also demonstrated that Borrelia burgdorferi is capable of developing aggregates on different abiotic and biotic substrates, and is also capable of forming floating aggregates. Analyzing the extracellular substance of the aggregates for potential exopolysaccharides revealed the existence of both sulfated and non-sulfated/carboxylated substrates, predominately composed of an alginate with calcium and extracellular DNA present. In summary, we have found substantial evidence that Borrelia burgdorferi is capable of forming biofilm in vitro. Biofilm formation by Borrelia species might play an important role in their survival in diverse environmental conditions by providing refuge to individual cells. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 16 | 33% |
| United Kingdom | 3 | 6% |
| Norway | 3 | 6% |
| Australia | 1 | 2% |
| Austria | 1 | 2% |
| Canada | 1 | 2% |
| France | 1 | 2% |
| Spain | 1 | 2% |
| Georgia | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 21 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 41 | 84% |
| Practitioners (doctors, other healthcare professionals) | 7 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Germany | 2 | <1% |
| Russia | 2 | <1% |
| Indonesia | 1 | <1% |
| United Kingdom | 1 | <1% |
| Norway | 1 | <1% |
| Brazil | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 194 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 18% |
| Researcher | 34 | 17% |
| Student > Bachelor | 32 | 16% |
| Student > Master | 24 | 12% |
| Student > Doctoral Student | 13 | 6% |
| Other | 34 | 17% |
| Unknown | 31 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 64 | 31% |
| Medicine and Dentistry | 31 | 15% |
| Biochemistry, Genetics and Molecular Biology | 23 | 11% |
| Immunology and Microbiology | 16 | 8% |
| Chemistry | 7 | 3% |
| Other | 29 | 14% |
| Unknown | 36 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 81. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2023.
All research outputs
#543,044
of 25,870,142 outputs
Outputs from PLOS ONE
#7,440
of 225,644 outputs
Outputs of similar age
#2,874
of 203,261 outputs
Outputs of similar age from PLOS ONE
#111
of 4,831 outputs
Altmetric has tracked 25,870,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 225,644 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,261 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 4,831 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.