@LukensJohnR Only the weird APP models with intraneuronal amyloid accumulation (3xTg and 5xFAD) support this “microglial dependence” idea. In knockin or other models plaques are unaffected by microglial depletion or even increased (https://t.co/zznzX2BUeN
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Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model https://t.co/dRohuxad0q https://t.co/TugTkwrELn
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RT @RobotRrid: RRIDs were included in the Molecular Neurodegeneration paper "Plaque associated microglia hyper-secrete extracel…" (https://…
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RRIDs were included in the Molecular Neurodegeneration paper "Plaque associated microglia hyper-secrete extracel…" (https://t.co/8kuSLRtxAx). We appreciate the author's support of reproducibility. #OpenScience #accelerateopenscience