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In-hospital measurement of left ventricular ejection fraction and one-year outcomes in acute coronary syndromes: results from the IMMEDIATE Trial

Overview of attention for article published in Cardiovascular Ultrasound, January 2016
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Title
In-hospital measurement of left ventricular ejection fraction and one-year outcomes in acute coronary syndromes: results from the IMMEDIATE Trial
Published in
Cardiovascular Ultrasound, January 2016
DOI 10.1186/s12947-016-0068-1
Pubmed ID
Authors

Mukherjee, Jayanta T, Beshansky, Joni R, Ruthazer, Robin, Alkofide, Hadeel, Ray, Madhab, Kent, David, Manning, Warren J, Huggins, Gordon S, Selker, Harry P, Jayanta T. Mukherjee, Joni R. Beshansky, Robin Ruthazer, Hadeel Alkofide, Madhab Ray, David Kent, Warren J. Manning, Gordon S. Huggins, Harry P. Selker;

Abstract

In patients with acute coronary syndrome (ACS), reduced left ventricular ejection fraction (LVEF) is a known marker for increased mortality. However, the relationship between LVEF measured during index ACS hospitalization and mortality and heart failure (HF) within 1 year are less well-defined. We performed a retrospective analysis of 445 participants in the IMMEDIATE Trial who had LVEF measured by left ventriculography or echocardiogram during hospitalization. Adjusting for age and coronary artery disease (CAD) history, lower LVEF was significantly associated with 1-year mortality or hospitalization for HF. For every 5 % LVEF reduction, the hazard ratio [HR] was 1.26 (95 % CI 1.15, 1.38, P < 0.001). Participants with LVEF < 40 % had higher hazard of 1-year mortality or HF hospitalization than those with LVEF > 40 (HR 3.59; 95 % CI 2.05, 6.27, P < 0.001). The HRs for the association of LVEF with the study outcomes were similar whether measured by left ventriculography or by echocardiography, (respectively, HR 1.32; 95 % CI 1.15, 1.51 and 1.21; 95 % CI 1.106, 1.35, interaction P = 0.32) and whether done within 24 h or not within 24 h (respectively, HR 1.28; 95 % CI 1.10, 1.50 and 1.23; 95 % CI 1.10, 1.38, interaction P = 0.67). Among patients with ACS, lower in-hospital LVEF is associated with increased 1-year mortality or hospitalization for HF, regardless of the method or timing of the LVEF assessment. This has prognostic implications for clinical practice and suggests the possibility of using various methods of LVEF determination in clinical research.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 18%
Student > Doctoral Student 3 18%
Researcher 3 18%
Professor > Associate Professor 2 12%
Student > Master 2 12%
Other 4 24%
Readers by discipline Count As %
Medicine and Dentistry 9 53%
Unspecified 2 12%
Nursing and Health Professions 1 6%
Mathematics 1 6%
Agricultural and Biological Sciences 1 6%
Other 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2016.
All research outputs
#6,113,186
of 8,457,084 outputs
Outputs from Cardiovascular Ultrasound
#162
of 211 outputs
Outputs of similar age
#166,836
of 259,978 outputs
Outputs of similar age from Cardiovascular Ultrasound
#8
of 13 outputs
Altmetric has tracked 8,457,084 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 211 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.