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Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study

Overview of attention for article published in BMJ Open, March 2021
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
25 news outlets
blogs
3 blogs
twitter
761 tweeters
facebook
1 Facebook page
reddit
5 Redditors

Citations

dimensions_citation
154 Dimensions

Readers on

mendeley
411 Mendeley
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Title
Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study
Published in
BMJ Open, March 2021
DOI 10.1136/bmjopen-2020-048391
Pubmed ID
Authors

Andrea Dennis, Malgorzata Wamil, Johann Alberts, Jude Oben, Daniel J Cuthbertson, Dan Wootton, Michael Crooks, Mark Gabbay, Michael Brady, Lyth Hishmeh, Emily Attree, Melissa Heightman, Rajarshi Banerjee, Amitava Banerjee, Dennis, A, Wamil, M, Alberts, J, Oben, J, Cuthbertson, DJ, Wootton, D, Crooks, M, Gabbay, M, Brady, M, Hishmeh, L, Attree, E, Heightman, M, Banerjee, R, Banerjee, A, COVERSCAN study investigators, ., Dennis, Andrea, Wamil, Malgorzata, Alberts, Johann, Oben, Jude, Cuthbertson, Daniel J, Wootton, Dan, Crooks, Michael, Gabbay, Mark, Brady, Michael, Hishmeh, Lyth, Attree, Emily, Heightman, Melissa, Banerjee, Rajarshi, Banerjee, Amitava, Investigators, COVERSCAN Study, , , COVERSCAN study investigators

Abstract

To assess medium-term organ impairment in symptomatic individuals following recovery from acute SARS-CoV-2 infection. Baseline findings from a prospective, observational cohort study. Community-based individuals from two UK centres between 1 April and 14 September 2020. Individuals ≥18 years with persistent symptoms following recovery from acute SARS-CoV-2 infection and age-matched healthy controls. Assessment of symptoms by standardised questionnaires (EQ-5D-5L, Dyspnoea-12) and organ-specific metrics by biochemical assessment and quantitative MRI. Severe post-COVID-19 syndrome defined as ongoing respiratory symptoms and/or moderate functional impairment in activities of daily living; single-organ and multiorgan impairment (heart, lungs, kidneys, liver, pancreas, spleen) by consensus definitions at baseline investigation. 201 individuals (mean age 45, range 21-71 years, 71% female, 88% white, 32% healthcare workers) completed the baseline assessment (median of 141 days following SARS-CoV-2 infection, IQR 110-162). The study population was at low risk of COVID-19 mortality (obesity 20%, hypertension 7%, type 2 diabetes 2%, heart disease 5%), with only 19% hospitalised with COVID-19. 42% of individuals had 10 or more symptoms and 60% had severe post-COVID-19 syndrome. Fatigue (98%), muscle aches (87%), breathlessness (88%) and headaches (83%) were most frequently reported. Mild organ impairment was present in the heart (26%), lungs (11%), kidneys (4%), liver (28%), pancreas (40%) and spleen (4%), with single-organ and multiorgan impairment in 70% and 29%, respectively. Hospitalisation was associated with older age (p=0.001), non-white ethnicity (p=0.016), increased liver volume (p<0.0001), pancreatic inflammation (p<0.01), and fat accumulation in the liver (p<0.05) and pancreas (p<0.01). Severe post-COVID-19 syndrome was associated with radiological evidence of cardiac damage (myocarditis) (p<0.05). In individuals at low risk of COVID-19 mortality with ongoing symptoms, 70% have impairment in one or more organs 4 months after initial COVID-19 symptoms, with implications for healthcare and public health, which have assumed low risk in young people with no comorbidities. NCT04369807; Pre-results.

Twitter Demographics

The data shown below were collected from the profiles of 761 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 411 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 411 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 59 14%
Researcher 35 9%
Student > Master 32 8%
Student > Ph. D. Student 26 6%
Unspecified 22 5%
Other 86 21%
Unknown 151 37%
Readers by discipline Count As %
Medicine and Dentistry 106 26%
Nursing and Health Professions 43 10%
Unspecified 23 6%
Biochemistry, Genetics and Molecular Biology 13 3%
Pharmacology, Toxicology and Pharmaceutical Science 9 2%
Other 55 13%
Unknown 162 39%

Attention Score in Context

This research output has an Altmetric Attention Score of 680. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2022.
All research outputs
#22,919
of 21,799,263 outputs
Outputs from BMJ Open
#61
of 21,185 outputs
Outputs of similar age
#1,009
of 331,379 outputs
Outputs of similar age from BMJ Open
#1
of 728 outputs
Altmetric has tracked 21,799,263 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 21,185 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,379 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 728 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.