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Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study

Overview of attention for article published in BMJ Open, March 2021
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#44 of 24,991)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
34 news outlets
blogs
3 blogs
policy
2 policy sources
twitter
1384 X users
facebook
1 Facebook page
reddit
5 Redditors

Citations

dimensions_citation
342 Dimensions

Readers on

mendeley
557 Mendeley
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Title
Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study
Published in
BMJ Open, March 2021
DOI 10.1136/bmjopen-2020-048391
Pubmed ID
Authors

Andrea Dennis, Malgorzata Wamil, Johann Alberts, Jude Oben, Daniel J Cuthbertson, Dan Wootton, Michael Crooks, Mark Gabbay, Michael Brady, Lyth Hishmeh, Emily Attree, Melissa Heightman, Rajarshi Banerjee, Amitava Banerjee

Abstract

To assess medium-term organ impairment in symptomatic individuals following recovery from acute SARS-CoV-2 infection. Baseline findings from a prospective, observational cohort study. Community-based individuals from two UK centres between 1 April and 14 September 2020. Individuals ≥18 years with persistent symptoms following recovery from acute SARS-CoV-2 infection and age-matched healthy controls. Assessment of symptoms by standardised questionnaires (EQ-5D-5L, Dyspnoea-12) and organ-specific metrics by biochemical assessment and quantitative MRI. Severe post-COVID-19 syndrome defined as ongoing respiratory symptoms and/or moderate functional impairment in activities of daily living; single-organ and multiorgan impairment (heart, lungs, kidneys, liver, pancreas, spleen) by consensus definitions at baseline investigation. 201 individuals (mean age 45, range 21-71 years, 71% female, 88% white, 32% healthcare workers) completed the baseline assessment (median of 141 days following SARS-CoV-2 infection, IQR 110-162). The study population was at low risk of COVID-19 mortality (obesity 20%, hypertension 7%, type 2 diabetes 2%, heart disease 5%), with only 19% hospitalised with COVID-19. 42% of individuals had 10 or more symptoms and 60% had severe post-COVID-19 syndrome. Fatigue (98%), muscle aches (87%), breathlessness (88%) and headaches (83%) were most frequently reported. Mild organ impairment was present in the heart (26%), lungs (11%), kidneys (4%), liver (28%), pancreas (40%) and spleen (4%), with single-organ and multiorgan impairment in 70% and 29%, respectively. Hospitalisation was associated with older age (p=0.001), non-white ethnicity (p=0.016), increased liver volume (p<0.0001), pancreatic inflammation (p<0.01), and fat accumulation in the liver (p<0.05) and pancreas (p<0.01). Severe post-COVID-19 syndrome was associated with radiological evidence of cardiac damage (myocarditis) (p<0.05). In individuals at low risk of COVID-19 mortality with ongoing symptoms, 70% have impairment in one or more organs 4 months after initial COVID-19 symptoms, with implications for healthcare and public health, which have assumed low risk in young people with no comorbidities. NCT04369807; Pre-results.

X Demographics

X Demographics

The data shown below were collected from the profiles of 1,384 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 557 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 557 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 65 12%
Researcher 50 9%
Student > Master 47 8%
Student > Ph. D. Student 34 6%
Other 25 4%
Other 85 15%
Unknown 251 45%
Readers by discipline Count As %
Medicine and Dentistry 132 24%
Nursing and Health Professions 51 9%
Biochemistry, Genetics and Molecular Biology 14 3%
Agricultural and Biological Sciences 11 2%
Pharmacology, Toxicology and Pharmaceutical Science 11 2%
Other 71 13%
Unknown 267 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 873. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#19,586
of 24,946,857 outputs
Outputs from BMJ Open
#44
of 24,991 outputs
Outputs of similar age
#752
of 432,615 outputs
Outputs of similar age from BMJ Open
#2
of 742 outputs
Altmetric has tracked 24,946,857 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 24,991 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 432,615 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 742 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.