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ΔNp63 drives metastasis in breast cancer cells via PI3K/CD44v6 axis

Overview of attention for article published in Oncotarget, August 2016
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  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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2 tweeters

Citations

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16 Dimensions

Readers on

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18 Mendeley
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Title
ΔNp63 drives metastasis in breast cancer cells <i>via</i> PI3K/CD44v6 axis
Published in
Oncotarget, August 2016
DOI 10.18632/oncotarget.11022
Pubmed ID
Authors

Di Franco, Simone, Turdo, Alice, Benfante, Antonina, Colorito, Maria L, Gaggianesi, Miriam, Apuzzo, Tiziana, Kandimalla, Raju, Chinnici, Aurora, Barcaroli, Daniela, Mangiapane, Laura Rosa, Pistone, Giuseppe, Vieni, Salvatore, Gulotta, Eliana, Dieli, Francesco, Medema, Jan Paul, Stassi, Giorgio, De Laurenzi, Vincenzo, Todaro, Matilde

Abstract

P63 is a transcription factor belonging to the family of p53, essential for the development and differentiation of epithelia. In recent years, it has become clear that altered expression of the different isoforms of this gene can play an important role in carcinogenesis. The p63 gene encodes for two main isoforms known as TA and ΔN p63 with different functions. The role of these different isoforms in sustaining tumor progression and metastatic spreading however has not entirely been clarified.Here we show that breast cancer initiating cells express ΔNp63 isoform that supports a more mesenchymal phenotype associated with a higher tumorigenic and metastatic potential. On the contrary, the majority of cells within the tumor appears to express predominantly TAp63 isoform. While ΔNp63 exerts its effects by regulating a PI3K/CD44v6 pathway, TAp63 modulates this pathway in an opposite fashion. As a result, tumorigenicity and invasive capacity of breast cancer cells is a balance of the two isoforms. Finally, we found that tumor microenvironmental cytokines significantly contribute to the establishment of breast cancer cell phenotype by positively regulating ΔNp63 and CD44v6 expression.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 28%
Researcher 4 22%
Student > Bachelor 2 11%
Student > Doctoral Student 2 11%
Student > Master 2 11%
Other 3 17%
Readers by discipline Count As %
Medicine and Dentistry 5 28%
Biochemistry, Genetics and Molecular Biology 5 28%
Agricultural and Biological Sciences 5 28%
Immunology and Microbiology 1 6%
Chemistry 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2016.
All research outputs
#4,098,024
of 8,177,609 outputs
Outputs from Oncotarget
#2,207
of 8,738 outputs
Outputs of similar age
#129,818
of 257,543 outputs
Outputs of similar age from Oncotarget
#71
of 213 outputs
Altmetric has tracked 8,177,609 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,738 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,543 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 213 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.