Title |
An atypical role for the myeloid receptor Mincle in central nervous system injury
|
---|---|
Published in |
Cerebrovascular and Brain Metabolism Reviews, August 2016
|
DOI | 10.1177/0271678x16661201 |
Pubmed ID | |
Authors |
Thiruma V Arumugam, Silvia Manzanero, Milena Furtado, Patrick J Biggins, Yu-Hsuan Hsieh, Mathias Gelderblom, Kelli PA MacDonald, Ekaterina Salimova, Yu-I Li, Othmar Korn, Deborah Dewar, I Mhairi Macrae, Robert B Ashman, Sung-Chun Tang, Nadia A Rosenthal, Marc J Ruitenberg, Tim Magnus, Christine A Wells |
Abstract |
The C-type lectin Mincle is implicated in innate immune responses to sterile inflammation, but its contribution to associated pathologies is not well understood. Herein, we show that Mincle exacerbates neuronal loss following ischemic but not traumatic spinal cord injury. Loss of Mincle was beneficial in a model of transient middle cerebral artery occlusion but did not alter outcomes following heart or gut ischemia. High functional scores in Mincle KO animals using the focal cerebral ischemia model were accompanied by reduced lesion size, fewer infiltrating leukocytes and less neutrophil-derived cytokine production than isogenic controls. Bone marrow chimera experiments revealed that the presence of Mincle in the central nervous system, rather than recruited immune cells, was the critical regulator of a poor outcome following transient middle cerebral artery occlusion. There was no evidence for a direct role for Mincle in microglia or neural activation, but expression in a subset of macrophages resident in the perivascular niche provided new clues on Mincle's role in ischemic stroke. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 40% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 40% |
Members of the public | 2 | 40% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 17% |
Student > Ph. D. Student | 9 | 16% |
Student > Bachelor | 6 | 10% |
Student > Master | 6 | 10% |
Other | 5 | 9% |
Other | 9 | 16% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 15 | 26% |
Biochemistry, Genetics and Molecular Biology | 8 | 14% |
Medicine and Dentistry | 7 | 12% |
Agricultural and Biological Sciences | 5 | 9% |
Immunology and Microbiology | 4 | 7% |
Other | 4 | 7% |
Unknown | 15 | 26% |