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Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2016
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Title
Gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal Schistosoma mansoni infection
Published in
Memórias do Instituto Oswaldo Cruz, February 2016
DOI 10.1590/0074-02760150293
Pubmed ID
Authors

Patrícia d‘Emery Alves Santos, Virgínia Maria Barros de Lorena, Érica de Souza Fernandes, Iana Rafaela Fernandes Sales, Wheverton Ricardo Correia do Nascimento, Yara de Miranda Gomes, Mônica Camelo Pessoa de Azevedo Albuquerque, Vlaudia Maria Assis Costa, Valdênia Maria Oliveira de Souza

Abstract

Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Master 6 14%
Student > Ph. D. Student 5 12%
Other 4 10%
Professor > Associate Professor 3 7%
Other 8 19%
Unknown 9 21%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Immunology and Microbiology 8 19%
Agricultural and Biological Sciences 3 7%
Nursing and Health Professions 1 2%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 5 12%
Unknown 10 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2016.
All research outputs
#11,127,497
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#794
of 862 outputs
Outputs of similar age
#220,007
of 262,940 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#9
of 9 outputs
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So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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