Title |
Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial
|
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Published in |
Nutrition Journal, October 2012
|
DOI | 10.1186/1475-2891-11-90 |
Pubmed ID | |
Authors |
Luz A González-Hernández, Luis F Jave-Suarez, Mary Fafutis-Morris, Karina E Montes-Salcedo, Luis G Valle-Gutierrez, Ariel E Campos-Loza, Luis Fermin Enciso-Gómez, Jaime F Andrade-Villanueva |
Abstract |
HIV-infection results in damage and dysfunction of the gastrointestinal system. HIV enteropathy includes pronounced CD4+ T-cell loss, increased intestinal permeability, and microbial translocation that promotes systemic immune activation, which is implicated in disease progression. A synbiotic is the combination of probiotics and prebiotics that could improve gut barrier function. Our study goal was to determine whether the use of a synbiotic, probiotics or a prebiotic can recover immunological parameters in HIV-infected subjects through of a reduction of microbial translocation and pro-inflammatory cytokine production. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 27% |
Netherlands | 1 | 9% |
Canada | 1 | 9% |
Australia | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 73% |
Scientists | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Mexico | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 200 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 16% |
Student > Master | 31 | 15% |
Student > Bachelor | 29 | 14% |
Student > Doctoral Student | 20 | 10% |
Student > Ph. D. Student | 17 | 8% |
Other | 31 | 15% |
Unknown | 43 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 57 | 28% |
Agricultural and Biological Sciences | 36 | 18% |
Biochemistry, Genetics and Molecular Biology | 18 | 9% |
Nursing and Health Professions | 16 | 8% |
Immunology and Microbiology | 10 | 5% |
Other | 16 | 8% |
Unknown | 51 | 25% |