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Lovastatin for adult patients with dengue: protocol for a randomised controlled trial

Overview of attention for article published in Trials, October 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

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2 X users
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1 patent
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2 Facebook pages

Citations

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45 Dimensions

Readers on

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100 Mendeley
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Title
Lovastatin for adult patients with dengue: protocol for a randomised controlled trial
Published in
Trials, October 2012
DOI 10.1186/1745-6215-13-203
Pubmed ID
Authors

James Whitehorn, Nguyen Van Vinh Chau, Nguyen Thanh Truong, Luong Thi Hue Tai, Nguyen Van Hao, Tran Tinh Hien, Marcel Wolbers, Laura Merson, Nguyen Thi Phuong Dung, Rosanna Peeling, Cameron Simmons, Bridget Wills, Jeremy Farrar

Abstract

Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and haemorrhage. One of the hallmarks of severe dengue is vascular endothelial disruption. There is currently no specific therapy and clinical management is limited to supportive care. Statins are a class of drug initially developed for lipid lowering. There has been considerable recent interest in their effects beyond lipid lowering. These include anti-inflammatory effects at the endothelium. In addition, it is possible that lovastatin may have an anti-viral effect against dengue. Observational data suggest that the use of statins may improve outcomes for such conditions as sepsis and pneumonia. This paper describes the protocol for a randomised controlled trial investigating a short course of lovastatin therapy in adult patients with dengue.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 2%
Colombia 1 1%
Malaysia 1 1%
French Polynesia 1 1%
Vietnam 1 1%
Brazil 1 1%
Romania 1 1%
United States 1 1%
Unknown 91 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 24%
Student > Master 22 22%
Student > Ph. D. Student 10 10%
Other 6 6%
Student > Bachelor 5 5%
Other 20 20%
Unknown 13 13%
Readers by discipline Count As %
Medicine and Dentistry 34 34%
Agricultural and Biological Sciences 20 20%
Biochemistry, Genetics and Molecular Biology 8 8%
Immunology and Microbiology 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 13 13%
Unknown 17 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2019.
All research outputs
#6,958,641
of 25,986,827 outputs
Outputs from Trials
#45
of 45 outputs
Outputs of similar age
#51,611
of 204,035 outputs
Outputs of similar age from Trials
#3
of 13 outputs
Altmetric has tracked 25,986,827 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 45 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one scored the same or higher as 0 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,035 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.