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The HIV-1 Rev Protein Enhances Encapsidation of Unspliced and Spliced, RRE-Containing Lentiviral Vector RNA

Overview of attention for article published in PLOS ONE, November 2012
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Title
The HIV-1 Rev Protein Enhances Encapsidation of Unspliced and Spliced, RRE-Containing Lentiviral Vector RNA
Published in
PLOS ONE, November 2012
DOI 10.1371/journal.pone.0048688
Pubmed ID
Authors

Bastian Grewe, Katrin Ehrhardt, Bianca Hoffmann, Maik Blissenbach, Sabine Brandt, Klaus Überla

Abstract

During the RNA encapsidation process of human immunodeficiency virus (HIV) viral genomic, unspliced RNA (gRNA) is preferentially incorporated into assembling virions. However, a certain amount of spliced viral transcripts can also be detected in viral particles. Recently, we observed that nuclear export of HIV and lentiviral vector gRNA by Rev is required for efficient encapsidation. Since singly-spliced HIV transcripts also contain the Rev-response element (RRE), we investigated if the encapsidation efficiency of RRE-containing spliced HIV-vector transcripts is also increased by the viral Rev protein.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 3%
France 1 3%
Germany 1 3%
Unknown 32 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 26%
Researcher 4 11%
Student > Doctoral Student 3 9%
Student > Master 3 9%
Other 2 6%
Other 6 17%
Unknown 8 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 31%
Agricultural and Biological Sciences 8 23%
Immunology and Microbiology 4 11%
Medicine and Dentistry 3 9%
Social Sciences 1 3%
Other 0 0%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2012.
All research outputs
#14,737,203
of 22,684,168 outputs
Outputs from PLOS ONE
#122,998
of 193,651 outputs
Outputs of similar age
#112,367
of 184,149 outputs
Outputs of similar age from PLOS ONE
#2,786
of 4,894 outputs
Altmetric has tracked 22,684,168 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,651 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,149 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,894 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.