C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Overview of attention for article published in FASEB Journal, November 2012

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DIOラットの内臓脂肪増加・炎症、耐糖能悪化、Ins抵抗性、CV障害は血中C3a、脂肪C5aR・C3aRと正相関。これらはC5aR・C3aR拮抗薬で改善。C5a/C3aは3T3L1においてIns様効果を示し、MφからPGE2分泌を促進。http://t.co/N6dpJY5x

Unexpeted complement: C5aR & C3aR antagonists ihb diet-ind'd obesity, metabolic dysfunction & adipocyte &acrophage sgln http://t.co/w5fMJCkf

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