Title |
Application of magnetically induced hyperthermia in the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections
|
---|---|
Published in |
International Journal of Nanomedicine, October 2012
|
DOI | 10.2147/ijn.s35510 |
Pubmed ID | |
Authors |
V Grazú, AM Silber, M Moros, L Asín, TE Torres, C Marquina, Ibarra, GF Goya |
Abstract |
Magnetic hyperthermia is currently a clinical therapy approved in the European Union for treatment of tumor cells, and uses magnetic nanoparticles (MNPs) under time-varying magnetic fields (TVMFs). The same basic principle seems promising against trypanosomatids causing Chagas disease and sleeping sickness, given that the therapeutic drugs available have severe side effects and that there are drug-resistant strains. However, no applications of this strategy against protozoan-induced diseases have been reported so far. In the present study, Crithidia fasciculata, a widely used model for therapeutic strategies against pathogenic trypanosomatids, was targeted with Fe(3)O(4) MNPs in order to provoke cell death remotely using TVMFs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 70 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 30% |
Researcher | 10 | 14% |
Student > Bachelor | 9 | 13% |
Student > Master | 5 | 7% |
Professor | 4 | 6% |
Other | 13 | 18% |
Unknown | 9 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 18% |
Biochemistry, Genetics and Molecular Biology | 11 | 15% |
Chemistry | 10 | 14% |
Materials Science | 10 | 14% |
Medicine and Dentistry | 7 | 10% |
Other | 8 | 11% |
Unknown | 12 | 17% |