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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Airborne Indoor Particles from Schools Are More Toxic than Outdoor Particles
|
|---|---|
| Published in |
American Journal of Respiratory Cell and Molecular Biology, August 2012
|
| DOI | 10.1165/rcmb.2012-0139oc |
| Pubmed ID | |
| Authors |
Sebastian Oeder, Rudolf A. Jörres, Ingrid Weichenmeier, Gudrun Pusch, Wolfgang Schober, Florian Pfab, Heidrun Behrendt, Rudolf Schierl, Angelika Kronseder, Dennis Nowak, Silvio Dietrich, Enrique Fernández-Caldas, Jutta Lintelmann, Ralf Zimmermann, Roland Lang, Jörg Mages, Hermann Fromme, Jeroen T. M. Buters |
| Abstract |
High concentrations of particulate matter (PM(10)) were measured in classrooms. This study addresses the hazard of indoor particles in comparison to the better-studied outdoor particles. Samples were taken from six schools during teaching hours. Genome-wide gene expression in human BEAS-2B lung epithelial cells was analyzed and verified by quantitative PCR. Polycyclic aromatic hydrocarbons, endotoxin, and cat allergen (Fel d 1) were analyzed by standard methods. Enhancement of allergic reactivity by PM(10) was confirmed in human primary basophils. Acceleration of human blood coagulation was determined with supernatants of PM(10)-exposed human peripheral blood monocytes. Indoor PM(10) induced serine protease inhibitor B2 (involved in blood coagulation) and inflammatory genes (such as CXCL6, CXCL1, IL6, IL8; all P < 0.001). Outdoor PM(10) induced xenobiotic metabolizing enzymes (cytochrome P450 [CYP] 1A1, CYP1B1, TIPARP; all P < 0.001). The induction of inflammatory genes by indoor PM(10) was explained by endotoxin (indoor 128.5 ± 42.2 EU/mg versus outdoor 13.4 ± 21.5 EU/mg; P < 0.001), the induction of CYP by outdoor polycyclic aromatic hydrocarbons (indoor 8.3 ± 4.9 ng/mg versus outdoor 16.7 ± 15.2 ng/mg; P < 0.01). The induction of serine protease inhibitor B2 was confirmed by a more rapid human blood coagulation (P < 0.05). Indoor PM(10) only affected allergic reactivity from human primary basophils from cat-allergic individuals. This was explained by varying Fel d 1 concentrations in indoor PM(10) (P < 0.001). Indoor PM(10), compared with outdoor PM(10), was six times higher and, on an equal weight basis, induced more inflammatory and allergenic reactions, and accelerated blood coagulation. Outdoor PM(10) had significantly lower effects, but induced detoxifying enzymes. Therefore, preliminary interventions for the reduction of classroom PM(10) seem reasonable, perhaps through intensified ventilation. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 66 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 26% |
| Student > Ph. D. Student | 13 | 19% |
| Student > Postgraduate | 6 | 9% |
| Professor | 4 | 6% |
| Other | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 14 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 16 | 23% |
| Agricultural and Biological Sciences | 9 | 13% |
| Medicine and Dentistry | 5 | 7% |
| Engineering | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2017.
All research outputs
#6,388,470
of 25,420,980 outputs
Outputs from American Journal of Respiratory Cell and Molecular Biology
#773
of 3,598 outputs
Outputs of similar age
#43,168
of 174,092 outputs
Outputs of similar age from American Journal of Respiratory Cell and Molecular Biology
#3
of 21 outputs
Altmetric has tracked 25,420,980 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 3,598 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,092 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.