RT @Pengyu19: #CRL4#AMBRA1 is a master regulator of D-type #cyclins | Nature https://t.co/NdCqcxbg5b
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#CRL4#AMBRA1 is a master regulator of D-type #cyclins | Nature https://t.co/NdCqcxbg5b
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In agreement with this study, we recently found that CDK2 activation in resistant tumors can be caused not only by increased levels of cyclin E, but also by increased levels of cyclin D (due to its mutations or inactivation of its ubiquitin ligase AMBRA1).
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RT @DanSimoneschi: Our work on AMBRA1 (https://t.co/KlLc7vXaz4) was highlighted in @theNCI Cancer Currents blog: https://t.co/hQ6Db4s6Lo @p…