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Epigenetic features of FoxP3 in children with cow’s milk allergy

Overview of attention for article published in Clinical Epigenetics, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

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8 tweeters

Citations

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37 Dimensions

Readers on

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38 Mendeley
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Title
Epigenetic features of FoxP3 in children with cow’s milk allergy
Published in
Clinical Epigenetics, January 2016
DOI 10.1186/s13148-016-0252-z
Pubmed ID
Authors

Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D’Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore, Roberto Berni Canani, Paparo, Lorella, Nocerino, Rita, Cosenza, Linda, Aitoro, Rosita, D'Argenio, Valeria, Del Monaco, Valentina, Di Scala, Carmen, Amoroso, Antonio, Di Costanzo, Margherita, Salvatore, Francesco, Berni Canani, Roberto

Abstract

DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Forty children (aged 3-18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Master 7 18%
Student > Postgraduate 5 13%
Student > Ph. D. Student 3 8%
Student > Bachelor 2 5%
Other 3 8%
Unknown 8 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 21%
Medicine and Dentistry 7 18%
Agricultural and Biological Sciences 4 11%
Unspecified 2 5%
Immunology and Microbiology 2 5%
Other 6 16%
Unknown 9 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2016.
All research outputs
#2,612,957
of 11,577,128 outputs
Outputs from Clinical Epigenetics
#151
of 533 outputs
Outputs of similar age
#68,215
of 263,530 outputs
Outputs of similar age from Clinical Epigenetics
#11
of 30 outputs
Altmetric has tracked 11,577,128 research outputs across all sources so far. Compared to these this one has done well and is in the 77th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 533 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,530 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.