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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0048225 |
| Pubmed ID | |
| Authors |
Heather J. M. Weir, Tracey K. Murray, Patrick G. Kehoe, Seth Love, Eric M. Verdin, Michael J. O’Neill, Jon D. Lane, Nina Balthasar |
| Abstract |
Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzheimer's disease (AD)-mediated stress. Pharmacological augmentation of mitochondrial ROS increases Sirt3 expression in primary hippocampal culture with SIRT3 over-expression being neuroprotective. Furthermore, Sirt3 expression mirrors spatiotemporal deposition of β-amyloid in an AD mouse model and is also upregulated in AD patient temporal neocortex. Thus, our data suggest a role for SIRT3 in mechanisms sensing and tackling ROS- and AD-mediated mitochondrial stress. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Finland | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 71 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 25% |
| Researcher | 14 | 18% |
| Student > Master | 10 | 13% |
| Professor > Associate Professor | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Other | 9 | 12% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 36% |
| Medicine and Dentistry | 11 | 14% |
| Neuroscience | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Other | 5 | 7% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2020.
All research outputs
#4,574,753
of 22,685,926 outputs
Outputs from PLOS ONE
#62,444
of 193,650 outputs
Outputs of similar age
#34,986
of 183,491 outputs
Outputs of similar age from PLOS ONE
#1,073
of 4,904 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,650 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 4,904 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.