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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa
|
|---|---|
| Published in |
PLOS ONE, November 2012
|
| DOI | 10.1371/journal.pone.0049123 |
| Pubmed ID | |
| Authors |
Elena B. M. Breidenstein, Laure Janot, Janine Strehmel, Lucia Fernandez, Patrick K. Taylor, Irena Kukavica-Ibrulj, Shaan L. Gellatly, Roger C. Levesque, Joerg Overhage, Robert E. W. Hancock |
| Abstract |
Pseudomonas aeruginosa PAO1 lon mutants are supersusceptible to ciprofloxacin, and exhibit a defect in cell division and in virulence-related properties, such as swarming, twitching and biofilm formation, despite the fact that the Lon protease is not a traditional regulator. Here we set out to investigate the influence of a lon mutation in a series of infection models. It was demonstrated that the lon mutant had a defect in cytotoxicity towards epithelial cells, was less virulent in an amoeba model as well as a mouse acute lung infection model, and impacted on in vivo survival in a rat model of chronic infection. Using qRT-PCR it was demonstrated that the lon mutation led to a down-regulation of Type III secretion genes. The Lon protease also influenced motility and biofilm formation in a mucin-rich environment. Thus alterations in several virulence-related processes in vitro in a lon mutant were reflected by defective virulence in vivo. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Portugal | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 90 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 16% |
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 12 | 13% |
| Student > Bachelor | 12 | 13% |
| Student > Postgraduate | 6 | 6% |
| Other | 17 | 18% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 34% |
| Biochemistry, Genetics and Molecular Biology | 24 | 26% |
| Immunology and Microbiology | 12 | 13% |
| Chemistry | 2 | 2% |
| Medicine and Dentistry | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 17 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2012.
All research outputs
#18,320,524
of 22,685,926 outputs
Outputs from PLOS ONE
#153,897
of 193,650 outputs
Outputs of similar age
#139,699
of 183,514 outputs
Outputs of similar age from PLOS ONE
#3,601
of 4,904 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,650 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,514 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,904 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.