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Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3

Overview of attention for article published in PLOS ONE, November 2012
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3 X users

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Title
Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
Published in
PLOS ONE, November 2012
DOI 10.1371/journal.pone.0049194
Pubmed ID
Authors

Jin Fu, Dan Chen, Bo Zhao, Zhihui Zhao, Jiahong Zhou, Yimiao Xu, Yinqiang Xin, Chang Liu, Lan Luo, Zhimin Yin

Abstract

Abnormal activity of STAT3 is associated with a number of human malignancies. Hsp90 plays a central role in stabilizing newly synthesized proteins and participates in maintaining the functional competency of a number of signaling transducers involved in cell growth, survival and oncogenesis, such as STAT3. Hsp90 interacts with STAT3 and stabilizes Tyr-phosphorylated STAT3. It has been reported that luteolin possesses anticancer activity through degradation of Tyr(705)-phosphorylated STAT3.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Brazil 1 4%
Unknown 21 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 22%
Student > Bachelor 5 22%
Student > Doctoral Student 3 13%
Researcher 3 13%
Student > Ph. D. Student 2 9%
Other 2 9%
Unknown 3 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 43%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Biochemistry, Genetics and Molecular Biology 2 9%
Environmental Science 1 4%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 6 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2022.
All research outputs
#15,335,522
of 23,575,346 outputs
Outputs from PLOS ONE
#131,000
of 201,789 outputs
Outputs of similar age
#113,488
of 185,268 outputs
Outputs of similar age from PLOS ONE
#2,802
of 4,901 outputs
Altmetric has tracked 23,575,346 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 201,789 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,268 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,901 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.