Title |
The ABCA1 Gene R230C Variant Is Associated with Decreased Risk of Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease (GEA) Study
|
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Published in |
PLOS ONE, November 2012
|
DOI | 10.1371/journal.pone.0049285 |
Pubmed ID | |
Authors |
Teresa Villarreal-Molina, Carlos Posadas-Romero, Sandra Romero-Hidalgo, Erika Antúnez-Argüelles, Araceli Bautista-Grande, Gilberto Vargas-Alarcón, Eric Kimura-Hayama, Samuel Canizales-Quinteros, Juan Gabriel Juárez-Rojas, Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, Aída Medina-Urrutia, María del Carmen González-Salazar, Rocío Martínez-Alvarado, Esteban Jorge-Galarza, Alessandra Carnevale |
Abstract |
ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated ABCA1 variation in cardiovascular risk. The functional ABCA1/R230C variant is frequent in the Mexican population and has been consistently associated with low HDL-C concentrations. Although it has been associated with other cardiovascular risk factors such as obesity and type 2 diabetes mellitus, it is not known whether it is associated with coronary artery disease (CAD). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 33% |
Mexico | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 4 | 3% |
Portugal | 1 | <1% |
Unknown | 110 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 20 | 17% |
Student > Bachelor | 17 | 15% |
Researcher | 15 | 13% |
Student > Ph. D. Student | 13 | 11% |
Student > Doctoral Student | 7 | 6% |
Other | 18 | 16% |
Unknown | 25 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 23% |
Biochemistry, Genetics and Molecular Biology | 25 | 22% |
Agricultural and Biological Sciences | 8 | 7% |
Nursing and Health Professions | 3 | 3% |
Immunology and Microbiology | 3 | 3% |
Other | 18 | 16% |
Unknown | 32 | 28% |