Tumour hypoxia causes DNA hypermethylation by reducing TET activity

Overview of attention for article published in Nature, August 2016

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RT @BEDecato: CpG island methylation in cancer linked to hypoxic conditions: microenviron. and genetic mutations work in concert! https://t…

RT @BEDecato: CpG island methylation in cancer linked to hypoxic conditions: microenviron. and genetic mutations work in concert! https://t…

CpG island methylation in cancer linked to hypoxic conditions: microenviron. and genetic mutations work in concert! https://t.co/cel6ZvIxjy

JCから：Tetは酸素を基質にする。腫瘍の低酸素環境ではTet活性が低下してDNAメチル化が上昇するという論文。0.5%酸素くらいになると活性は半分に。通常の低酸素応答の仕組みになっているのかどうか。 https://t.co/AaHPzBSJT5

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