↓ Skip to main content

Deciphering the pathogenesis of tendinopathy: a three-stages process

Overview of attention for article published in BMC Sports Science, Medicine and Rehabilitation, December 2010
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

twitter
16 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
210 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Deciphering the pathogenesis of tendinopathy: a three-stages process
Published in
BMC Sports Science, Medicine and Rehabilitation, December 2010
DOI 10.1186/1758-2555-2-30
Pubmed ID
Authors

Sai-Chuen Fu, Christer Rolf, Yau-Chuk Cheuk, Pauline PY Lui, Kai-Ming Chan

Abstract

Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injury" per se. The typical clinical, histological and biochemical presentation relates to a localized chronic pain condition which may lead to tendon rupture, the latter attributed to mechanical weakness. Characterization of pathological "tendinotic" tissues revealed coexistence of collagenolytic injuries and an active healing process, focal hypervascularity and tissue metaplasia. These observations suggest a failed healing process as response to a triggering injury. The pathogenesis of tendinopathy can be described as a three stage process: injury, failed healing and clinical presentation. It is likely that some of these "initial injuries" heal well and we speculate that predisposing intrinsic or extrinsic factors may be involved. The injury stage involves a progressive collagenolytic tendon injury. The failed healing stage mainly refers to prolonged activation and failed resolution of the normal healing process. Finally, the matrix disturbances, increased focal vascularity and abnormal cytokine profiles contribute to the clinical presentations of chronic tendon pain or rupture. With this integrative pathogenesis theory, we can relate the known manifestations of tendinopathy and point to the "missing links". This model may guide future research on tendinopathy, until we could ultimately decipher the complete pathogenesis process and provide better treatments.

Twitter Demographics

The data shown below were collected from the profiles of 16 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Chile 1 <1%
Italy 1 <1%
Austria 1 <1%
South Africa 1 <1%
New Zealand 1 <1%
Argentina 1 <1%
Spain 1 <1%
United States 1 <1%
Other 0 0%
Unknown 201 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 41 20%
Student > Bachelor 36 17%
Other 25 12%
Researcher 22 10%
Student > Ph. D. Student 21 10%
Other 54 26%
Unknown 11 5%
Readers by discipline Count As %
Medicine and Dentistry 81 39%
Nursing and Health Professions 35 17%
Sports and Recreations 24 11%
Agricultural and Biological Sciences 15 7%
Biochemistry, Genetics and Molecular Biology 9 4%
Other 25 12%
Unknown 21 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2019.
All research outputs
#1,329,940
of 14,039,431 outputs
Outputs from BMC Sports Science, Medicine and Rehabilitation
#51
of 204 outputs
Outputs of similar age
#13,750
of 146,784 outputs
Outputs of similar age from BMC Sports Science, Medicine and Rehabilitation
#1
of 1 outputs
Altmetric has tracked 14,039,431 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 204 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them