Interesting, as examples of transcription factor degradation are few. Also conversion of an agonist ligand into a degrader. Would like to see functional data showing these compounds behave as antagonists and not agonists of any residual non-degraded LXR. h
10,717 followers
44 followers
RT @Trankill34: Development of Agonist-Based PROTACs Targeting Liver X Receptor https://t.co/P3v6GlqFSb
3,515 followers
Development of Agonist-Based PROTACs Targeting Liver X Receptor https://t.co/P3v6GlqFSb
4,299 followers
New Research: Development of Agonist-Based PROTACs Targeting Liver X Receptor: Liver X receptors (LXRs) belong to the nuclear hormone receptor superfamily and function as ligand-dependent transcription factors that regulate cholesterol… https://t.co/YSiPWE