Title |
Identification of a new cell line permissive to porcine reproductive and respiratory syndrome virus infection and replication which is phenotypically distinct from MARC-145 cell line
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Published in |
Virology Journal, November 2012
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DOI | 10.1186/1743-422x-9-267 |
Pubmed ID | |
Authors |
Chantale Provost, Jian Jun Jia, Nedzad Music, Cynthia Lévesque, Marie-Ève Lebel, Jérôme RE del Castillo, Mario Jacques, Carl A Gagnon |
Abstract |
Airborne transmitted pathogens, such as porcine reproductive and respiratory syndrome virus (PRRSV), need to interact with host cells of the respiratory tract in order to be able to enter and disseminate in the host organism. Pulmonary alveolar macrophages (PAM) and MA104 derived monkey kidney MARC-145 cells are known to be permissive to PRRSV infection and replication and are the most studied cells in the literature. More recently, new cell lines developed to study PRRSV have been genetically modified to make them permissive to the virus. The SJPL cell line origin was initially reported to be epithelial cells of the respiratory tract of swine. Thus, the goal of this study was to determine if SJPL cells could support PRRSV infection and replication in vitro. |
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Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
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Denmark | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
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Researcher | 8 | 19% |
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Professor | 3 | 7% |
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