Title |
Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach
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Published in |
BMC Systems Biology, November 2012
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DOI | 10.1186/1752-0509-6-141 |
Pubmed ID | |
Authors |
Tatiana A Karelina, Kirill V Zhudenkov, Oleg O Demin, Dmitry V Svetlichny, Balaji Agoram, David Fairman, Oleg V Demin |
Abstract |
5-lipoxygenase (5-LO) is a key enzyme in the synthesis of leukotrienes and 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (oxoETE). These inflammatory signaling molecules play a role in the pathology of asthma and so 5-LO inhibition is a promising target for asthma therapy. The 5-LO redox inhibitor zileuton (Zyflo IR/CR(®)) is currently marketed for the treatment of asthma in adults and children, but widespread use of zileuton is limited by its efficacy/safety profile, potentially related to its redox characteristics. Thus, a quantitative, mechanistic description of its functioning may be useful for development of improved anti-inflammatory targeting this mechanism. |
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Cyprus | 1 | 50% |
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Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Russia | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
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Researcher | 9 | 45% |
Student > Ph. D. Student | 3 | 15% |
Other | 1 | 5% |
Lecturer | 1 | 5% |
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Other | 3 | 15% |
Unknown | 2 | 10% |
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Mathematics | 1 | 5% |
Other | 1 | 5% |
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