@Uromigos @drenriquegrande @DrRosenbergMSK @MattGalsky @shilpaonc I have 2 current clients with UC whose tumors have CDKN2A/B loss and pembrolizumab didn't work. Both younger and otherwise robust health. Seems perhaps this should be considered to help
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Us (https://t.co/Thzcsswnr0), and other have shown that deletions in 9p21 are associated with⬇️survival on immune checkpoint inhibitors (ICI) in multiple tumor types, mostly implicating CDKN2A as the culprit.
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Us (https://t.co/ThzcssvPBs) and others have shown that deletions in 9p are associated ⬇️ survival on immune checkpoint inhibition in multiple tumor types, mostly implicating CDKN2A as the culprit.
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IMMUNOTHERAPY: CDKN2A loss of function was associated with poor response to checkpoint inhibition in bladder cancer in two independent cohorts; no association was observed in other cancer types studied. https://t.co/pTwrxzMmrE