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Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes

Overview of attention for article published in BMC Medicine, November 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
10 tweeters

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
46 Mendeley
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Title
Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes
Published in
BMC Medicine, November 2012
DOI 10.1186/1741-7015-10-140
Pubmed ID
Authors

Nasser M Al-Daghri, Rachele Cagliani, Diego Forni, Majed S Alokail, Uberto Pozzoli, Khalid M Alkharfy, Shaun Sabico, Mario Clerici, Manuela Sironi

Abstract

The NPC1 gene encodes a protein involved in intracellular lipid trafficking; its second endosomal loop (loop 2) is a receptor for filoviruses. A polymorphism (His215Arg) in NPC1 was associated with obesity in Europeans. Adaptations to diet and pathogens represented powerful selective forces; thus, we analyzed the evolutionary history of the gene and exploited this information for the identification of variants/residues of functional importance in human disease.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 22%
Researcher 7 15%
Professor 6 13%
Student > Master 6 13%
Student > Bachelor 5 11%
Other 12 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 24%
Medicine and Dentistry 11 24%
Agricultural and Biological Sciences 6 13%
Immunology and Microbiology 3 7%
Social Sciences 2 4%
Other 10 22%
Unknown 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2014.
All research outputs
#1,813,545
of 11,272,140 outputs
Outputs from BMC Medicine
#1,127
of 1,804 outputs
Outputs of similar age
#18,755
of 116,934 outputs
Outputs of similar age from BMC Medicine
#41
of 59 outputs
Altmetric has tracked 11,272,140 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,804 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,934 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.