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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
|
|---|---|
| Published in |
npj Systems Biology and Applications, August 2016
|
| DOI | 10.1038/npjsba.2016.18 |
| Pubmed ID | |
| Authors |
Shin-ichiro Imai |
| Abstract |
The original concept of the NAD World was proposed in 2009, providing a comprehensive framework to investigate critical issues of biological robustness and trade-offs in mammalian aging and longevity control. Significant progress has been made over the past 7 years, advancing our understanding of the mechanisms by which biological robustness is maintained, and providing extensive support to the concept of the NAD World. Three key organs and tissues have been identified as basic elements in this control system for mammalian aging and longevity: the hypothalamus as the control center of aging, skeletal muscle as an effector, and adipose tissue as a modulator. While the hypothalamus sends a signal to skeletal muscle through the sympathetic nervous system, adipose tissue remotely regulates hypothalamic function by coordinating NAD(+) biosynthesis at a systemic level. Skeletal muscle might also communicate with other organs and tissues by secreting various myokines. The mammalian NAD(+)-dependent protein deacetylase SIRT1 and the key NAD(+) biosynthetic enzyme NAMPT mediate these inter-tissue communications. In this review, the function of each organ or tissue and their inter-tissue communications will be discussed in terms of understanding mammalian aging and longevity control. With such an emphasis on the system architecture, the concept is now reformulated as the NAD World 2.0, providing several important predictions. The concept of the NAD World 2.0 will provide a new foundation to understand a control system for mammalian aging and longevity and accelerate the development of an effective anti-aging intervention for humans. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 12% |
| Canada | 1 | 6% |
| Australia | 1 | 6% |
| United States | 1 | 6% |
| Germany | 1 | 6% |
| Japan | 1 | 6% |
| Unknown | 10 | 59% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Scientists | 3 | 18% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 139 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 22% |
| Student > Ph. D. Student | 24 | 17% |
| Student > Master | 16 | 11% |
| Student > Bachelor | 13 | 9% |
| Student > Doctoral Student | 5 | 4% |
| Other | 21 | 15% |
| Unknown | 31 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 30% |
| Agricultural and Biological Sciences | 17 | 12% |
| Medicine and Dentistry | 14 | 10% |
| Neuroscience | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 15 | 11% |
| Unknown | 38 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2022.
All research outputs
#2,896,600
of 24,593,959 outputs
Outputs from npj Systems Biology and Applications
#69
of 329 outputs
Outputs of similar age
#48,743
of 350,008 outputs
Outputs of similar age from npj Systems Biology and Applications
#2
of 6 outputs
Altmetric has tracked 24,593,959 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 329 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.