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Integration of a Systems Biological Network Analysis and QTL Results for Biomass Heterosis in Arabidopsis thaliana

Overview of attention for article published in PLOS ONE, November 2012
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Title
Integration of a Systems Biological Network Analysis and QTL Results for Biomass Heterosis in Arabidopsis thaliana
Published in
PLOS ONE, November 2012
DOI 10.1371/journal.pone.0049951
Pubmed ID
Authors

Sandra Andorf, Rhonda C. Meyer, Joachim Selbig, Thomas Altmann, Dirk Repsilber

Abstract

To contribute to a further insight into heterosis we applied an integrative analysis to a systems biological network approach and a quantitative genetics analysis towards biomass heterosis in early Arabidopsis thaliana development. The study was performed on the parental accessions C24 and Col-0 and the reciprocal crosses. In an over-representation analysis it was tested if the overlap between the resulting gene lists of the two approaches is significantly larger than expected by chance. Top ranked genes in the results list of the systems biological analysis were significantly over-represented in the heterotic QTL candidate regions for either hybrid as well as regarding mid-parent and best-parent heterosis. This suggests that not only a few but rather several genes that influence biomass heterosis are located within each heterotic QTL region. Furthermore, the overlapping resulting genes of the two integrated approaches were particularly enriched in biomass related pathways. A chromosome-wise over-representation analysis gave rise to the hypothesis that chromosomes number 2 and 4 probably carry a majority of the genes involved in biomass heterosis in the early development of Arabidopsis thaliana.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Germany 1 3%
Australia 1 3%
Unknown 33 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 25%
Researcher 9 25%
Professor 4 11%
Professor > Associate Professor 3 8%
Lecturer 2 6%
Other 6 17%
Unknown 3 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 64%
Computer Science 4 11%
Biochemistry, Genetics and Molecular Biology 2 6%
Medicine and Dentistry 1 3%
Engineering 1 3%
Other 0 0%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2012.
All research outputs
#20,172,971
of 22,685,926 outputs
Outputs from PLOS ONE
#172,801
of 193,650 outputs
Outputs of similar age
#141,200
of 159,110 outputs
Outputs of similar age from PLOS ONE
#3,987
of 4,755 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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