Title |
An open label study to determine the effects of an oral proteolytic enzyme system on whey protein concentrate metabolism in healthy males
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Published in |
Journal of the International Society of Sports Nutrition, May 2022
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DOI | 10.1186/1550-2783-5-10 |
Pubmed ID | |
Authors |
Julius Oben, Shil C Kothari, Mark L Anderson |
Abstract |
Current research suggests that protein intake of 1.5 - 2.8 g/kg/day (3.5 times the current recommended daily allowance) is effective and safe for individuals trying to increase or maintain lean muscle mass. To achieve these levels of daily protein consumption, supplementing the diet with processed whey protein concentrate (WPC) in liquid form has become a popular choice for many people. Some products have a suggested serving size as high as 50 g of protein. However, due to possible inhibition of endogenous digestive enzymes from over-processing and rapid small intestine transit time, the average amount of liquid WPC that is absorbed may be only 15 g. The combined effect of these factors may contribute to incomplete digestion, thereby limiting the absorption rate of protein before it reaches the ceacum and is eliminated as waste. The purpose of this study was to determine if Aminogen(R), a patented blend of digestive proteases from Aspergillus niger and Aspergillus oryzae, would significantly increase the in-vivo absorption rate of processed WPC over control values. It also investigated if any increase would be sufficient to significantly alter nitrogen (N2) balance and C-reactive protein (CRP) levels over control values as further evidence of increased WPC absorption rate. |
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Geographical breakdown
Country | Count | As % |
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United States | 3 | 18% |
Japan | 2 | 12% |
Vanuatu | 1 | 6% |
United Kingdom | 1 | 6% |
Unknown | 10 | 59% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 88% |
Practitioners (doctors, other healthcare professionals) | 2 | 12% |
Mendeley readers
Geographical breakdown
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Israel | 1 | <1% |
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Unknown | 107 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 21 | 19% |
Researcher | 20 | 18% |
Student > Master | 18 | 16% |
Student > Ph. D. Student | 11 | 10% |
Other | 11 | 10% |
Other | 14 | 13% |
Unknown | 15 | 14% |
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Agricultural and Biological Sciences | 25 | 23% |
Medicine and Dentistry | 18 | 16% |
Sports and Recreations | 16 | 15% |
Nursing and Health Professions | 14 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Other | 13 | 12% |
Unknown | 17 | 15% |