Title |
Hypoxia and its implications in rheumatoid arthritis
|
---|---|
Published in |
Journal of Biomedical Science, August 2016
|
DOI | 10.1186/s12929-016-0281-0 |
Pubmed ID | |
Authors |
Celia María Quiñonez-Flores, Susana Aideé González-Chávez, César Pacheco-Tena |
Abstract |
Alterations in tissue oxygen pressure contribute to a number of diseases, including rheumatoid arthritis (RA). Low partial pressure of oxygen, a condition known as hypoxia, is a relevant feature in RA since it is involved in angiogenesis, inflammation, apoptosis, cartilage degradation, energy metabolism, and oxidative damage. Therefore, alterations in hypoxia-related signaling pathways are considered potential mechanisms of disease pathogenesis. The objective of this review is to highlight and update our current knowledge of the role of hypoxia in the pathogenesis of RA. We describe the experimental evidence that RA synovial tissue exists in a hypoxic state, as well as the origin and involvement of synovial hypoxia in different aspects of the pathogenic process. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Bulgaria | 1 | 1% |
Unknown | 95 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 22% |
Student > Master | 11 | 11% |
Researcher | 10 | 10% |
Student > Bachelor | 10 | 10% |
Student > Doctoral Student | 8 | 8% |
Other | 9 | 9% |
Unknown | 27 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 16% |
Immunology and Microbiology | 12 | 13% |
Medicine and Dentistry | 12 | 13% |
Agricultural and Biological Sciences | 11 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
Other | 14 | 15% |
Unknown | 27 | 28% |