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Modeling and Molecular Dynamics of HPA-1a and -1b Polymorphisms: Effects on the Structure of the β3 Subunit of the αIIbβ3 Integrin

Overview of attention for article published in PLOS ONE, November 2012
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2 X users

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34 Dimensions

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23 Mendeley
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Title
Modeling and Molecular Dynamics of HPA-1a and -1b Polymorphisms: Effects on the Structure of the β3 Subunit of the αIIbβ3 Integrin
Published in
PLOS ONE, November 2012
DOI 10.1371/journal.pone.0047304
Pubmed ID
Authors

Vincent Jallu, Pierre Poulain, Patrick F. J. Fuchs, Cecile Kaplan, Alexandre G. de Brevern

Abstract

The HPA-1 alloimmune system carried by the platelet integrin αIIbβ3 is the primary cause of alloimmune thrombocytopenia in Caucasians and the HPA-1b allele might be a risk factor for thrombosis. HPA-1a and -1b alleles are defined by a leucine and a proline, respectively, at position 33 in the β3 subunit. Although the structure of αIIbβ3 is available, little is known about structural effects of the L33P substitution and its consequences on immune response and integrin functions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 30%
Researcher 4 17%
Student > Master 3 13%
Unspecified 2 9%
Student > Doctoral Student 1 4%
Other 4 17%
Unknown 2 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 30%
Biochemistry, Genetics and Molecular Biology 4 17%
Neuroscience 3 13%
Unspecified 2 9%
Psychology 1 4%
Other 3 13%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2014.
All research outputs
#16,262,032
of 24,929,945 outputs
Outputs from PLOS ONE
#143,809
of 216,035 outputs
Outputs of similar age
#113,221
of 183,884 outputs
Outputs of similar age from PLOS ONE
#2,707
of 4,739 outputs
Altmetric has tracked 24,929,945 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 216,035 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,884 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4,739 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.