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Associated Clinical and Laboratory Markers of Donor on Allograft Function After Heart Transplant

Overview of attention for article published in Brazilian journal of cardiovascular surgery, April 2016
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Title
Associated Clinical and Laboratory Markers of Donor on Allograft Function After Heart Transplant
Published in
Brazilian journal of cardiovascular surgery, April 2016
DOI 10.5935/1678-9741.20160025
Pubmed ID
Authors

Braulio, Renato, Sanches, Marcelo Dias, Teixeira Junior, Antonio Lúcio, Costa, Paulo Henrique Nogueira, Moreira, Maria da Consolação Vieira, Rocha, Monaliza Angela, Andrade, Silvio Amadeu de, Gelape, Cláudio Léo

Abstract

Primary graft dysfunction is a major cause of mortality after heart transplantation. To evaluate correlations between donor-related clinical/biochemical markers and the occurrence of primary graft dysfunction/clinical outcomes of recipients within 30 days of transplant. The prospective study involved 43 donor/recipient pairs. Data collected from donors included demographic and echocardiographic information, noradrenaline administration rates and concentrations of soluble tumor necrosis factor receptors (sTNFR1 and sTNFR2), interleukins (IL-6 and IL-10), monocyte chemoattractant protein-1, C-reactive protein and cardiac troponin I. Data collected from recipients included operating, cardiopulmonary bypass, intensive care unit and hospitalization times, inotrope administration and left/right ventricular function through echocardiography. Recipients who developed moderate/severe left ventricular dysfunction had received organs from significantly older donors (P =0.020). Recipients from donors who required moderate/high doses of noradrenaline (>0.23 µg/kg/min) around harvesting time exhibited lower post-transplant ventricular ejection fractions (P =0.002) and required longer CPB times (P =0.039). Significantly higher concentrations of sTNFR1 (P =0.014) and sTNFR2 (P =0.030) in donors were associated with reduced intensive care unit times (≤5 days) in recipients, while higher donor IL-6 (P =0.029) and IL-10 (P =0.037) levels were correlated with reduced hospitalization times (≤25 days) in recipients. Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001). High levels of sTNFR1, sTNFR2, IL-6 and IL-10 in donors were associated with enhanced evolution in recipients. Allografts from older donors, or from those treated with noradrenaline doses >0.23 µg/kg/min, were more frequently affected by primary graft dysfunction within 30 days of surgery.

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Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 11%
Student > Master 3 11%
Student > Bachelor 3 11%
Librarian 2 7%
Other 2 7%
Other 5 18%
Unknown 10 36%
Readers by discipline Count As %
Medicine and Dentistry 13 46%
Biochemistry, Genetics and Molecular Biology 2 7%
Materials Science 1 4%
Veterinary Science and Veterinary Medicine 1 4%
Unknown 11 39%